Oncogenes: Yeast aids cancer research

Discovery of oncogenes: The advent of molecular cancer research.

In their classic paper on the identification of the transforming principle of Rous sarcoma virus (RSV) published 1970 in PNAS (1), Peter Duesberg at the University of California, Berkeley, and Peter Vogt, then at the University of Washington, Seattle, drew a seemingly simple yet groundbreaking conclusion. When they analyzed the genomic RNAs of transforming, acutely oncogenic RSV and of transfor...

Oncogenes and cancer.

From the Department of Molecular Virology, Immunology, and Medical Genetics and the Human Cancer Genetics Program, Ohio State University Medical Center, Columbus. Address reprint requests to Dr. Croce at the Human Cancer Genetics Program and Department of Molecular Virology, Immunology, and Medical Genetics, Ohio State University Medical Center, 385L Wiseman Hall, 400 W. 12th Ave., Columbus, OH...

Cancer and AIDS: National Cancer Institute's investment in research.

Oncogenes in Human Cancer: A Review ras

Mutations in codon 12, 13, or 61 of one of the three ras genes, 11-ra.v, k-ra.v, and N-ra.v,convert these genes into active oncogenes. Rapid assays for the detection of these point mutations have been developed recently and used to investigate the role mutated ras genes play in the pathogenesis of human tumors. It appeared that ras gene mutations can be found in a variety of tumor types, althou...

ras Oncogenes in Human Cancer: A Review1

Mutations in codon 12, 13, or 61 of one of the three ras genes, 11-ra.v, k-ra.v, and N-ra.v,convert these genes into active oncogenes. Rapid assays for the detection of these point mutations have been developed recently and used to investigate the role mutated ras genes play in the pathogenesis of human tumors. It appeared that ras gene mutations can be found in a variety of tumor types, althou...